The benefits of
Testosterone Replacement Therapy

Testosterone is a hormone – a chemical messenger that influences the development and function of various target organs. While traditionally known as the “male sex hormone,” its critical role in overall health has often been underestimated or overlooked by conventional medicine.

Testosterone plays a vital part in numerous aspects of your wellbeing, including:

• Mental health and cognitive function
• Energy levels
• Libido
• Sexual function and fertility
• Muscle development
• Cardiovascular health
• Bone strength
• Weight management

Unfortunately, the misuse of testosterone as a Performance Enhancing Drug has negatively affected its legitimate medical use in treating true hormone deficiencies. Fundamentally, testosterone’s primary role is to support growth and repair throughout the body, as cells continually regenerate and heal. This makes testosterone an important anabolic hormone, with far-reaching effects beyond just muscle growth.

We use the latest guidelines from the British Society for Sexual Medicine when diagnosing and treating men with low testosterone. A thorough diagnostic blood work-up is essential – not only to confirm the deficiency but also to identify potentially reversible causes and exclude any contraindications to therapy.

The primary goal of Testosterone Replacement Therapy (TRT) is to correct this deficiency. Traditionally, this involves administering testosterone monotherapy to restore testosterone levels within normal physiological ranges, supporting long-term physical and psychological health. Qualitatively, TRT aims to reverse the negative symptoms associated with low testosterone. Quantitatively, it seeks to normalise biological markers to help the body maintain homeostasis and overall wellbeing.

TRT is a medical treatment designed to bring male androgen levels back to a healthy balance for sustained physical and mental health. It should be considered a lifelong therapy and only initiated after thoroughly addressing reversible causes and improving lifestyle factors such as nutrition, exercise, and stress management that may be contributing to your condition.

Historically, testosterone replacement has focused solely on administering testosterone. However, exogenous testosterone suppresses the brain’s production of Luteinising Hormone (LH) and Follicle Stimulating Hormone (FSH), which regulate testicular function. This suppression can negatively affect fertility, testicular size, and other important roles LH plays throughout the body, including within the brain.

Human Chorionic Gonadotropin (hCG) mimics LH and helps counteract this suppression. Incorporating hCG alongside testosterone in therapy supports fertility preservation, maintains testicular size, and preserves broader physiological functions. In our clinical experience, optimal male hormone replacement therapy includes both testosterone and hCG.

Maintaining homeostasis – the body’s ability to sustain a stable internal environment despite external changes – relies on many physiological systems working together. The body naturally cycles between anabolic (building up) and catabolic (breaking down) states. Normalising testosterone levels is essential to helping the body achieve and maintain this vital balance.

Your Testosterone Replacement Therapy (TRT) protocol is carefully customised to meet your unique needs, taking into account your genetics, physiology, and how your body utilises hormones. The primary goal of TRT is to restore and maintain hormonal balance, recognising that your body requires stability to function optimally. Naturally, testosterone levels fluctuate throughout the day – known as diurnal variation – reflecting your body’s need to shift between anabolic (building) and catabolic (breaking down) states at different times. TRT aims to closely mimic this natural rhythm, supporting the ongoing physiological processes essential for your health.

We use daily injections of Testosterone Cypionate or Enanthate as our gold-standard testosterone esters. These have relatively short half-lives, which allows us to manage and adjust doses easily to minimise side effects, while still maintaining hormonal stability. For some patients, weekly Testosterone Undecanoate injections may be more appropriate and are offered based on clinical need. All testosterone therapies are combined with daily Human Chorionic Gonadotropin (hCG), a treatment we’ve found to be the most effective in stabilising male androgen levels and improving overall wellbeing.

Our preferred method of administration is subcutaneous injections, as they tend to be less painful than shallow intramuscular injections and cause less long-term tissue scarring. Subcutaneous injections also result in slower hormone absorption, which helps reduce the risk of side effects related to excess oestrogen. Some patients continue to self-administer shallow intramuscular injections, which may be suitable depending on the specific testosterone ester used and individual clinical requirements.

We firmly believe that Microdosing TRT is the future of Testosterone Replacement Therapy.

Microdosing involves administering small, carefully measured amounts of medications – in this case, testosterone and human chorionic gonadotropin (hCG) – to maintain stable hormone levels. This approach is both safe and effective. You don’t need an in-depth understanding of pharmacokinetics to appreciate why many current NHS recommendations may not be optimal. The core principle behind microdosing is to use the minimum effective dose in the most appropriate manner to achieve steady, natural male androgen levels. The goal is to closely replicate your body’s own physiological testosterone production, promoting long-term physical health and psychological wellbeing.

It’s important to recognise that all hormones are interconnected, whether through direct or indirect pathways, and the body strives to maintain a stable internal environment despite external changes. Our aim is normalisation, not achieving supraphysiological (excessively high) hormone levels, which can ultimately be harmful. Your DNA is wired for balance – it wants you to be within the normal physiological range.

Supraphysiological testosterone levels can lead to a variety of negative health consequences, including:

• Decline in mental wellbeing and mood disturbances
• Increased blood pressure and added cardiac stress
• Elevated haematocrit, which raises the risk of blood clots
• Unfavourable changes in lipid profiles
• Worsening of lower urinary tract symptoms
• Potential associations with prostate cancer risk
• Development of gynecomastia (enlargement of male breast tissue)

By embracing microdosing, we prioritise safety and efficacy, supporting your body’s natural balance and reducing the risk of adverse effects.

1. Testosterone is vital for long-term physical and mental health, supporting energy, mood, cognition, sexual function, muscle, bone, and heart health.

2. As an anabolic hormone, testosterone promotes growth, repair, and regeneration of tissues throughout the body.

3. Testosterone Replacement Therapy (TRT) aims to restore testosterone levels to a natural, healthy range, supporting overall wellbeing and hormonal balance.

4. Gold-standard TRT typically involves daily Testosterone Cypionate/Enanthate or weekly Testosterone Undecanoate injections combined with daily Human Chorionic Gonadotropin (hCG) to preserve testicular function and fertility.

5. Micro-dosing uses the minimum effective hormone doses to maintain stable, physiological levels, reducing side effects and promoting long-term safety and consistency.