Chemical Immune Reactivity Screening

Identify The Loss Of Immune Tolerance Associated With Chemical Exposure

Utilising The Leading Cyrex Laboratory For Gold Standard Chemical Immune Reactivity Screening


 

Who are Cyrex?

Cyrex is a Clinical Immunology Laboratory Specialising in Functional Immunology and Autoimmunity. Cyrex offers multi-tissue antibody testing for the early detection and monitoring of today’s complex autoimmune conditions. Cyrex develops innovative arrays through continuous collaboration with leading experts in medical research and clinical practice.

 

What is Chemical Immune Reactivity Screening?

Cyrex’s Chemical Immune Reactivity Screen (Array 11) utilises breakthrough technology that identifies immune responses to chemicals bound to human proteins.  This is the first test to measure the actual immune response to chemicals, instead of simply detecting the level of chemical exposure/load which excretes from the body.

 

What is the difference between measuring chemical levels and Array 11?

Tests that measure levels of chemicals in stool, urine or hair, while providing evidence of exposure, fail in determining a person’s health risk. Two people may have the same exposure to a particular chemical and one will not be affected while the other can have significant health consequences from it. Looking at the humoral immune response tells us more than just levels do, it tells us how the person is reacting to the given exposure. Humoral immunity, the system in which antibodies are produced to fight/recognize invading elements, is tested for a variety of clinical purposes from allergies to viral infections. This same trusted testing methodology can be used to detect antibodies to chemicals bound to human tissue.

 

What are the possible immune responses to chemical exposures?

Depending on the person’s genetic ability to handle chemicals, amount and duration of exposure and body burden of accumulated insults, adverse effects on the immune system can result from exposure to chemicals (immunotoxicity) such as immune suppression or immune stimulation.

Immune suppression leaves the patient more susceptible to infections. Combinations of chemical and stealth organism exposures have been shown to contribute to illness.

Immune stimulation may result in allergic reactions or autoimmunity. Autoimmune responses can be induced by environmental chemicals through a variety of effects including cellular, biochemical and molecular – Bigazzi PE. Autoimmunity caused by xenobiotics. Toxicology, 1997; 119:1-21.

 

What do the results of Array 11 say about the duration of chemical exposure?

A: Any antibody production is an indication of exposure to the chemical and the binding of the chemical to human tissue, resulting in body burden to the chemical. According to Greim, IgM is produced as a primary response in the first days of defense. If previous exposures have occurred, a secondary immune response results in IgG production. High levels of these antibodies indicate an immune reaction to an antigen which threatens the homeostasis of the body and may result in autoimmune reactivity – Greim P, Wulferink M, Sachs B, et al. Allergic and autoimmune reactions to xenobiotics: how do they arise? Immunol Today, 1998; 19(3):133-141.

 

Does the level of antibodies correlate with the quantity of exposure?

No. Each person has an individual response to chemicals. Some patients may have low-level exposure, but high body-burden (elevated antibodies), while others may have high or acute-level exposure, but no measurable body burden (normal antibody levels).

 

How do chemicals enter the body?

Depending upon the chemical and its use, infiltration of the body can occur by contact (through the skin), inhalation (through the lungs), and ingestion (through the gastrointestinal tract).

 

What does the Cyrex Array 11 measure?

Antigens Tested (IgG + IgA Combined, IgM Tested Separately for Each Antigen):

  • Aflatoxins
  • Formaldehyde + Glutaraldehyde
  • Isocyanate
  • Trimellitic + Phthalic Anhydrides
  • Benzene Ring Compounds
  • BPA Binding Protein
  • Bisphenol A
  • Tetrabromobisphenol A
  • Tetrachloroethylene
  • Parabens
  • Mercury Compounds
  • Mixed Heavy Metals (Nickel, Cobalt, Cadmium, Lead, Arsenic)

 

How do I organise Cyrex Chemical Immune Reactivity Screening through The Men’s Health Clinic?

Appointments can be made by calling us on 01202 091593  Full payment is taken at the time of booking.

It will take no longer than 15 minutes to have your blood drawn and no fasting is required.  You will receive your comprehensive test results by email within two weeks.

 

Where can I find further information?

Further information on Cyrex’s testing system can be found on their website.

 

 

Cyrex Array 11 Screening:  £475

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