Chemical Immune Reactivity Screening
Identify The Loss Of Immune Tolerance Associated With Chemical Exposure
Identify The Loss Of Immune Tolerance Associated With Chemical Exposure
Cyrex is a Clinical Immunology Laboratory Specialising in Functional Immunology and Autoimmunity. Cyrex offers multi-tissue antibody testing for the early detection and monitoring of today’s complex autoimmune conditions. Cyrex develops innovative arrays through continuous collaboration with leading experts in medical research and clinical practice.
Cyrex’s Chemical Immune Reactivity Screen (Array 11) utilises breakthrough technology that identifies immune responses to chemicals bound to human proteins. This is the first test to measure the actual immune response to chemicals, instead of simply detecting the level of chemical exposure/load which excretes from the body.
Depending on the person’s genetic ability to handle chemicals, amount and duration of exposure and body burden of accumulated insults, adverse effects on the immune system can result from exposure to chemicals (immunotoxicity) such as immune suppression or immune stimulation.
Immune suppression leaves the patient more susceptible to infections. Combinations of chemical and stealth organism exposures have been shown to contribute to illness.
Immune stimulation may result in allergic reactions or autoimmunity. Autoimmune responses can be induced by environmental chemicals through a variety of effects including cellular, biochemical and molecular – Bigazzi PE. Autoimmunity caused by xenobiotics. Toxicology, 1997; 119:1-21.
A: Any antibody production is an indication of exposure to the chemical and the binding of the chemical to human tissue, resulting in body burden to the chemical. According to Greim, IgM is produced as a primary response in the first days of defense. If previous exposures have occurred, a secondary immune response results in IgG production. High levels of these antibodies indicate an immune reaction to an antigen which threatens the homeostasis of the body and may result in autoimmune reactivity – Greim P, Wulferink M, Sachs B, et al. Allergic and autoimmune reactions to xenobiotics: how do they arise? Immunol Today, 1998; 19(3):133-141.
No. Each person has an individual response to chemicals. Some patients may have low-level exposure, but high body-burden (elevated antibodies), while others may have high or acute-level exposure, but no measurable body burden (normal antibody levels).
Depending upon the chemical and its use, infiltration of the body can occur by contact (through the skin), inhalation (through the lungs), and ingestion (through the gastrointestinal tract).
Antigens Tested (IgG + IgA Combined, IgM Tested Separately for Each Antigen):
Appointments can be made by calling us on 01202 091593 Full payment is taken at the time of booking.
It will take no longer than 15 minutes to have your blood drawn and no fasting is required. You will receive your comprehensive test results by email within two weeks.
Further information on Cyrex’s testing system can be found on their website.
Speak to our team, book online or email us with any questions that you may have.
